Nitric oxide system and diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Nitric oxide system and diabetic nephropathy
About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase...
متن کاملRole of nitric oxide in diabetic nephropathy.
Diabetic nephropathy is the leading cause of end-stage renal disease in the Western hemisphere. Endothelial dysfunction is the central pathophysiologic denominator for all cardiovascular complications of diabetes including nephropathy. Abnormalities of nitric oxide (NO) production modulate renal structure and function in diabetes but, despite the vast literature, major gaps exist in our underst...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملDiabetic nephropathy: nitric oxide and renal medullary hypoxia.
DIABETES, SPECIFICALLY DIABETIC nephropathy, is the most frequent cause of end-stage renal disease (ESRD) in developed countries (10). Classically, studies into the mechanisms underlying diabetic nephropathy have focused on glomerular injury and the development of albuminuria; however, changes in tubulointerstitial structure and function are also evident even during the early stages in diabetes...
متن کاملRole of Nitric Oxide in the Pathogenesis of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats
OBJECTIVES Several reports suggest that enhanced generation or actions of nitric oxide (NO) have been implicated in the pathogenesis of glomerular hyperfiltration and hyperperfusion that occurs in early diabetes. However, the precise role of altered NO generation in the pathogenesis of diabetic nephropathy is unclear. The present study was aimed at investigating the role of nitric oxide in the ...
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ژورنال
عنوان ژورنال: Diabetology & Metabolic Syndrome
سال: 2014
ISSN: 1758-5996
DOI: 10.1186/1758-5996-6-17